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The U.S. National Library of Medicine provides a database of clinical trials worldwide. Use the fields below to search the database. Expand your results and select terms or phrases and right-click to search using Google, MalaCards, MedlinePlus, PubMed, or Wikipedia.

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Clinical Trials Search Results

Query: "TILT[LastUpdatePostDate]SEARCH[Study]AREA[SponsorSearch]Agios Pharmaceuticals, Inc."
Count: 50
Selected: 0
NCT IDTitle
NCT06286046A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy
NCT06286033A Safety Study of Single and Multiple Doses of AG-181 in Healthy Participants
NCT05490446A Study of AG-946 in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)
NCT05144256A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period
NCT03692052A Study to Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AG-348 in Adult Participants With Non-transfusion-dependent Thalassemia
NCT02476916A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency
NCT05777993A Study to Provide Continued Access to Mitapivat for Participants Who Previously Completed an Agios-Sponsored Mitapivat Study
NCT05175105A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period
NCT05031780A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
NCT04770779A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)
NCT04770753A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)
NCT03853798Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007
NCT03481738Pyruvate Kinase Deficiency Global Longitudinal Registry
NCT04536792A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers and in Participants With Sickle Cell Disease
NCT04995315Pyruvate Kinase Deficiency Global Longitudinal Registry Substudy of Protocol AG348-C-008
NCT05610657A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function
NCT04964323Pyruvate Kinase (PK) Deficiency Global Longitudinal Registry: Patient-Reported Outcomes (PRO)
NCT03548220A Study to Evaluate Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)
NCT03559699A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)
NCT04128787A Study to Compare the Relative Bioavailability of Two AG-881 Formulations and Evaluate the Effect of Food and Omeprazole on the Pharmacokinetics of AG-881
NCT04696393A Study to Compare the Pharmacokinetics and Safety of Mitapivat 100 mg Tablet Formulation With Mitapivat 2 × 50 mg Tablet Formulation in Healthy Adult Participants
NCT04472832A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Mitapivat (AG-348) in Healthy Adult Participants
NCT04565678A Study to Assess the Relative Bioavailability and Effect of Food on the Coated Granule Formulation of Mitapivat in Healthy Participants
NCT03834584A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma
NCT04145128A Study to Evaluate AG-881 in Healthy Japanese and Non-Asian Participants
NCT03361358Pre-Screening Study to Identify MTAP Loss in Advanced Solid Tumors or Lymphoma
NCT03991312Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants
NCT03960502A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881
NCT04015687A Study to Evaluate the Effect of AG-881 on the Pharmacokinetics of a Single Dose of Lamotrigine in Healthy Adults
NCT02492737Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation
NCT03703505A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-348 and Concomitant Single Intravenous Microdose of [13C6]AG-348
NCT03245424Ivosidenib Expanded Access Program in Relapsed/Refractory AML With an IDH1 Mutation
NCT03282513A Study of AG-120 (Ivosidenib) in Subjects With Mild or Moderate Hepatic Impairment or Normal Hepatic Function
NCT03397329Study to Evaluate the Relative Bioavailability and Safety of the AG-348 Tablet and Capsule Formulations in Healthy Adults
NCT03071770Japanese Bridging Study of Ivosidenib (AG-120) in Healthy Subjects
NCT03250598Study to Evaluate the Pharmacokinetics, Safety, and QTc Effect of AG-348 in Healthy Subjects of Japanese Origin and Non-Asian Origin
NCT02630927A Safety and Tolerability Study of AG-519 in Healthy Subjects
NCT02831972Drug-Drug Interaction Study of AG120 in Healthy Subjects
NCT02579707Food Effect Study of AG120 in Healthy Subjects
NCT02489513Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-AG-120
NCT02218346Food Effect Study of AG-221 in Healthy Male Subjects
NCT02149966A Phase I Study of AG-348 in Healthy Volunteers
NCT02108106A Phase I Study of AG-348 in Healthy Volunteers
NCT04902833Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms
NCT03564821IDH1 Inhibition Using Ivosidenib as Maintenance Therapy for IDH1-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation
NCT01915498Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutation
NCT04278781AG-120 in People With IDH1 Mutant Chondrosarcoma
NCT02053480Pyruvate Kinase Deficiency Natural History Study
NCT04056910Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors
NCT04000165A Dose-Finding Study of AG-348 in Sickle Cell Disease